Diablo III runs absolutely flawless, and it’s REALLY simple to get running:
Set up a prefix for the game:
WINEARCH=win32 WINEPREFIX=~/.diablo3 winetricks vcrun2015 directx9 xact xinput
Turn on CSMT:
WINEARCH=win32 WINEPREFIX=~/.diablo3 winecfg
Staging>Enable CSMT
Install blizzardapp if you need to:
WINEARCH=win32 WINEPREFIX=~/.diablo3 wine blizzardappinstallername.exe
Run the blizzardapp, make sure to disable hardware acceleration on the app, then install diablo 3 with it:
WINEARCH=win32 WINEPREFIX=~/.diablo3 wine /path/to/blizzardapp/you/installed.exe
Run Diablo 3:
WINEARCH=win32 WINEPREFIX=~/.diablo3 wine /path/to/diablo/3/Diablo III.exe -launch
Turn vsync and antialiasing off in game
if using lutris disable lutris runtime under system options. Enjoy!